國家衛生研究院 NHRI:Item 3990099045/6098
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    題名: MrBac: A web server for draft metabolic network reconstructions for bacteria
    作者: Liao, YC;Chen, JCY;Tsai, MH;Tang, YH;Chen, FC;Hsiung, CA
    貢獻者: Division of Biostatistics and Bioinformatics
    摘要: Genome-scale metabolic network reconstruction can be used for simulating cellular behaviors by simultaneously monitoring thousands of biochemical reactions, and is therefore important for systems biology studies in microbes. However, the labor-intensive and time-consuming reconstruction process has hindered the progress of this important field. Here we present a web server, MrBac (Metabolic network Reconstructions for Bacteria), to streamline the network reconstruction process for draft genome-scale metabolic networks and to provide annotation information from multiple databases for further curation of the draft reconstructions. MrBac integrates comparative genomics, retrieval of genome annotations, and generation of standard systems biology file format ready for network analyses. We also used MrBac to automatically generate a draft metabolic model of Salmonella enteric serovar Typhimurium LT2. The high similarity between this automatic model and the experimentally validated models further supports the usefulness and accuracy of MrBac. The high efficiency and accuracy of MrBac may accelerate the advances of systems biology studies on microbiology.
    日期: 2011-09
    關聯: Bioengineered Bugs. 2011 Sep;2(5):284-287.
    Link to: http://dx.doi.org/10.4161/bbug.2.5.16113
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80055012872
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