國家衛生研究院 NHRI:Item 3990099045/6141
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    題名: Enhancement of focused ultrasound with microbubbles on the treatments of anticancer nanodrug in mouse tumors
    作者: Lin, CY;Li, JR;Tseng, HC;Wu, MF;Lin, WL
    貢獻者: Division of Medical Engineering Research
    摘要: Ultrasound sonication with microbubbles (MBs) has the potential to enhance the delivery of nanoparticles into the sonicated tumors. In this study, we investigated the feasibility of focused ultrasound (FUS) sonication with MBs to improve nanodrug delivery and tumor treatment. Tumor-bearing mice were first injected with MBs (SonoVue) intravenously, were then sonicated at the tumors with FUS sonication, and were finally injected with the PEGylated liposomal doxorubicin (DOX). The accumulation of DOX in tumors with time, the tumor growth responses for initial treated tumor size and DOX dosage, and the response for an additional sonication after DOX injection were studied. The results demonstrate that FUS sonication with MBs can significantly enhance DOX accumulation in the sonicated tumor at 24 hours after treatment. A significant hindrance to tumor growth is achieved for a small tumor with a low dose, whereas large tumors require a higher dose.
    日期: 2012-08
    關聯: Nanomedicine-Nanotechnology Biology and Medicine. 2012 Aug;8(6):900-907.
    Link to: http://dx.doi.org/10.1016/j.nano.2011.10.005
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1549-9634&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000306662100013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864083435
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