國家衛生研究院 NHRI:Item 3990099045/6226
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    题名: Complete microscale profiling of tumor microangiogenesis: A microradiological methodology reveals fundamental aspects of tumor angiogenesis and yields an array of quantitative parameters for its characterization
    作者: Chien, CC;Kempson, IM;Wang, CL;Chen, HH;Hwu, Y;Chen, NY;Lee, TK;Petibois, C;Tsai, KKC;Liu, MS;Chang, KY;Yang, CS;Margaritondo, G
    贡献者: National Institute of Cancer Research;Center for Nanomedicine Research
    摘要: Complete profiling would substantially facilitate the fundamental understanding of tumor angiogenesis and of possible anti-angiogenesis cancer treatments. We developed an integrated synchrotron-based methodology with excellent performances: detection of very small vessels by high spatial resolution (~ 1 μm) and nanoparticle contrast enhancement, in vivo dynamics investigations with high temporal resolution (~ 1 ms), and three-dimensional quantitative morphology parametrization by computer tracing. The smallest (3-10 μm) microvessels were found to constitute > 80% of the tumor vasculature and exhibit many structural anomalies. Practical applications are presented, including vessel microanalysis in xenografted tumors, monitoring the effects of anti-angiogenetic agents and in vivo detection of tumor vascular rheological properties.
    日期: 2013-05
    關聯: Biotechnology Advances. 2013 May;31(3):396-401.
    Link to: http://dx.doi.org/10.1016/j.biotechadv.2011.12.001
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0734-9750&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000317441900007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84875055465
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