國家衛生研究院 NHRI:Item 3990099045/6255
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6255


    Title: Caffeic acid phenethyl ester causes p21Cip1 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells
    Other Titles: Caffeic acid phenethyl ester causes p21(Cip1) induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells
    Authors: Lin, HP;Jiang, SS;Chuu, CP
    Contributors: Institute of Cellular and Systems Medicine;National Institute of Cancer Research
    Abstract: Caffeic acid phenethyl ester (CAPE) treatment suppressed proliferation, colony formation, and cell cycle progression in PC-3 human prostate cancer cells. CAPE decreased protein expression of cyclin D1, cyclin E, SKP2, c-Myc, Akt1, Akt2, Akt3, total Akt, mTOR, Bcl-2, Rb, as well as phosphorylation of Rb, ERK1/2, Akt, mTOR, GSK3α, GSK3β, PDK1; but increased protein expression of KLF6 and p21Cip1. Microarray analysis indicated that pathways involved in cellular movement, cell death, proliferation, and cell cycle were affected by CAPE. Co-treatment of CAPE with chemotherapeutic drugs vinblastine, paclitaxol, and estramustine indicated synergistic suppression effect. CAPE administration may serve as a potential adjuvant therapy for prostate cancer.
    Date: 2012-01
    Relation: PLoS ONE. 2012 Jan;7(2):Article number e31286.
    Link to: http://dx.doi.org/10.1371/journal.pone.0031286
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000302180600033
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863071290
    Appears in Collections:[Chih-Pin Chuu] Periodical Articles
    [Shih-Sheng Jiang] Periodical Articles

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