國家衛生研究院 NHRI:Item 3990099045/6263

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6263

Title:	Characterization of glycan binding specificities of influenza B viruses with correlation with hemagglutinin genotypes and clinical features
Authors:	Wang, YF;Chang, CF;Chi, CY;Wang, HC;Wang, JR;Su, IJ
Contributors:	Division of Infectious Diseases
Abstract:	The carbohydrate binding specificities are different among avian and human influenza A viruses and may affect the tissue tropism and transmission of these viruses. The glycan binding biology for influenza B, however, has not been systematically characterized. Glycan binding specificities of influenza B viral isolates were analyzed and correlated to hemagglutinin (HA) genotypes and clinical manifestations. A newly developed solution glycan array was applied to characterize the receptor binding specificities of influenza B virus clinical isolates from 2001 to 2007 in Taiwan. Thirty oligosaccharides which include alpha-2,3 and alpha-2,6 linkage glycans were subjected to analysis. The glycan binding patterns of 53 influenza B isolates could be categorized into three groups and were well correlated to their HA genotypes. The Yamagata-like strains predominantly bound to alpha-2,6-linkage glycan (24:29, 83%) while Victoria-like strains preferentially bound to both alpha-2,3- and alpha-2,6-linkage glycans (13:24, 54%). A third group of viruses bound to sulfated glycans and these all belonged to Victoria-like strains. Based on the HA sequences, Asn-163, Glu-198, Ala-202, and Lys-203 were conserved among Victoria-like strains which may influence their carbohydrate recognition. The viruses bound to dual type glycans were more likely to be associated with the development of bronchopneumonia and gastrointestinal illness than those bound only to alpha-2,6 sialyl glycans (P < 0.05). Glycan binding analyses provide additional information to monitor the antigenic shift, tissue tropism, and transmission capability of influenza B viruses, and will contribute to virus surveillance and vaccine strain selection.
Date:	2012-04
Relation:	Journal of Medical Virology. 2012 Apr;84(4):679-685.
Link to:	http://dx.doi.org/10.1002/jmv.23219
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0146-6615&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000300696200018
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863129288
Appears in Collections:	[Chia-Yu Chi] Periodical Articles [Ih-Jen Su(2002-2015)] Periodical Articles

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