國家衛生研究院 NHRI:Item 3990099045/6283
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 859776      在线人数 : 829
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/6283


    题名: Erlotinib treatment in patients with advanced lung adenocarcinoma with CISH-positive and cish-negative EGFR gene alterations
    作者: Hou, MM;Huang, SF;Kuo, HP;Yang, CTA;Tsai, YH;Yu, CT;Lin, HC;Chen, CH;Wang, CL;Chung, FT;Hsieh, JJ;Hsu, T;Cheng, HY;Ou, LY;Wang, HM;Lin, YC;Chang, NJ;Chang, JWC
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Background: Epidermal growth factor receptor (EGFR) positivity as assessed by chromogenic in situ hybridization (CISH) has been demonstrated to be associated with EGFR mutation status. This study was conducted to compare the responsiveness of CISH-positive and CISH-negative lung adenocarcinomas to erlotinib. Patients and Methods: Patients received erlotinib (150 mg/day) alone until disease progression or intolerable toxicity. EGFR gene status was examined by CISH. The response rate (RR), progression-free survival (PFS), overall survival (OS) and toxicity profiles were assessed. Results: Thirty-one patients underwent response evaluations and CISH analyses, 12 of whom harboured CISH-positive adenocarcinomas. The overall RR (p=0.035), median PFS (p=0.091) and median OS (p=0.408) were higher in the CISH-positive group. No difference in toxicity profiles was observed between these two groups. Conclusion: EGFR status as assessed by CISH can predict the response to erlotinib in patients with advanced lung adenocarcinoma.
    日期: 2012-03
    關聯: Anticancer Research. 2012 Mar;32(3):1107-1112.
    Link to: http://ar.iiarjournals.org/content/32/3/1107
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0250-7005&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000301619200059
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84863345190
    显示于类别:[黃秀芬] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP84858767165.pdf132KbAdobe PDF469检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈