國家衛生研究院 NHRI:Item 3990099045/6320
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    题名: A novel rotating electrochemically anodizing process to fabricate titanium oxide surface nanostructures enhancing the bioactivity of osteoblastic cells
    作者: Chang, CH;Lee, HC;Chen, CC;Wu, YH;Hsu, YM;Chang, YP;Yang, TI;Fang, HW
    贡献者: Division of Medical Engineering Research
    摘要: Titanium oxide (TiO 2) surface layers with various surface nanostructures (nanotubes and nanowires) have been developed using an anodizing technique. The pore size and length of TiO 2 nanotubes can be tailored by changing the anodizing time and applied voltage. We developed a novel method to transform the upper part of the formed TiO 2 nanotubes into a nanowire-like structure by rotating the titanium anode during anodizing process. The transformation of nanotubes contributed to the preferential chemical dissolution of TiO 2 on the areas with intense interface tension stress. Furthermore, we further compared the effect of various TiO 2 surface nanostructures including flat, nanotubes, and nanowires on bioactive applications. The MG-63 osteoblastic cells cultured on the TiO 2 nanowires exhibited a polygonal shape with extending filopodia and showed highest levels of cell viability and alkaline phosphatase activity (ALP). The TiO 2 nanowire structure formed by our novel method can provide beneficial effects for MG-63 osteoblastic cells in attachment, proliferation, and secretion of ALP on the TiO 2 surface layer.
    日期: 2012-07
    關聯: Journal of Biomedical Materials Research - Part A. 2012 Jul;100A(7):1687-1695.
    Link to: http://dx.doi.org/10.1002/jbm.a.34117
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1549-3296&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000304396500006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84862800011
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