國家衛生研究院 NHRI:Item 3990099045/6356
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6356


    Title: Current applications of human pluripotent stem cells: Possibilities and challenges
    Authors: Ho, PJ;Yen, ML;Yet, SF;Yen, BL
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Stem cells are self-renewable cells with the differentiation capacity to develop intosomatic cells with biological functions. This ability to sustain a renewable source of multi- and/or pluri-potential differentiation potential has brought new hope to the field of regenerative medicine in terms of cell therapy and tissue engineering. Moreover, stem cells are invaluable tools as in vitro models for studying diverse fields, from basic scientific questions such as developmental processes and lineage commitment, to practical application including drug screening and testing. The stem cells with widest differentiation potential are pluripotent stem cells (PSCs), which are rare cells with the ability to generate somatic cells from all three germ layers. PSCs are considered the most optimal choice for therapeutic potential of stem cells, and, bringing new impetus to the field of regenerative medicine. In this article, we discuss the therapeutic potential of human PSCs (hPSCs) including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), reviewing the current pre-clinical and clinical data using these stem cells. We describe the classification of different sources of hPSCs, ongoing research, and currently encountered clinical obstacles of these novel and versatile human stem cells.
    Date: 2012-05
    Relation: Cell Transplantation. 2012 May;21(5):801-814.
    Link to: http://dx.doi.org/10.3727/096368911X627507
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0963-6897&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000306455600002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84862559258
    Appears in Collections:[Betty Lin-Ju Yen] Periodical Articles
    [Shaw-Fang Yet] Periodical Articles

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