國家衛生研究院 NHRI:Item 3990099045/6367
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6367


    Title: Determination of perfluorochemicals in human milk using Isotope-dilution liquid chromatography tandem mass spectrometry
    Authors: Wang, YC;Lin, AYC;Wang, SL;Ding, WH
    Contributors: Division of Environmental Health and Occupational Medicine
    Abstract: A highly precise and accurate analytical method utilizing an isotope-dilution liquid chromatography tandem mass spectrometry was developed and validated to determine two perfluorochemicals (PFCs): perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) in human milk samples. Identification of the analytes was confirmed under negative electrospray with multiple reaction monitoring (MRM) mode by the monitoring of one precursor ion and two product ions, and matching of relative ion intensities of the ions concerned in samples and calibration standards. Quantitation was based on the measurement of concentration ratios of the natural and labeled-analogues in the samples and calibration mixtures. The isotope-labeled internal standards were also used to correct the matrix effect and variations associated with the analysis. Intra- and inter-day repeatabilities of replicate analyses of the PFOA and PFOS in milk samples were below 8%. The limit of quantitation was 2 pg/mL in a 5 mL milk sample. The PFOA and PFOS were detected in all 20 human milk samples at concentrations from 27.0 to 207 pg/mL. This is the first study to measure the occurrence of PFOA and PFOS in human milk from Taiwan.
    Date: 2012-04
    Relation: Journal of the Chinese Chemical Society. 2012 Apr;59(4):544-549.
    Link to: http://dx.doi.org/10.1002/jccs.201100528
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-4536&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000302194400014
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84860702689
    Appears in Collections:[Shu-Li Wang] Periodical Articles

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