國家衛生研究院 NHRI:Item 3990099045/6368
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    题名: Heat acclimation decreased oxidative DNA damage resulting from exposure to high heat in an occupational setting
    作者: Huang, YK;Lin, CW;Chang, CC;Chen, PF;Wang, CJ;Hsueh, YM;Chiang, HC
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Heat acclimation is a physiologically and biochemically adapted process when species transition from one environmental temperature to one of the increased temperature. There is very limited epidemiological evidence on the heat-related impacts during exposure to extremely high heat in an occupational environment. This study sought to identify a potential biomarker of heat acclimation and the burden of heat on the body. The aim of this study was to elucidate oxidative DNA damage and heat acclimation through a self-comparison study design in navy boiler tenders, subjects exposed to extremely high heat in an occupational setting. Fifty-eight male soldiers who work in a boiler room were recruited for this study. The subjects were initially assessed with a health examination and body composition assessment before sailing. In order to compare the within-subject differences before and after heat exposure, the index-related heat exposure was collected before and after a routine 5-h work shift and 7-day sailing. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), a useful marker of oxidative DNA damage was the measurement by liquid chromatography/tandem mass spectrometry. The median of the change in urinary 8-OHdG was 0.78 μg/g creatinine, as the urinary 8-OHdG after sailing was significantly higher than before sailing ( p < 0.01). The urinary 8-OHdG was significantly decreased in heat-acclimated boiler tenders. Oxidative DNA damage was significantly decreased in heat-acclimated subjects. Urinary 8-OHdG can be used as a biomarker to assess the effect of heat stress as a result of occupational exposure to extremely high heat conditions.
    日期: 2012-12
    關聯: European Journal of Applied Physiology. 2012 Dec;112(12):4119-4126.
    Link to: http://dx.doi.org/10.1007/s00421-012-2401-1
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1439-6319&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000310994800019
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84869229612
    显示于类别:[江宏哲] 期刊論文

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