國家衛生研究院 NHRI:Item 3990099045/6380
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    題名: In vitro feasibility study of the use of a magnetic electrospun chitosan nanofiber composite for hyperthermia treatment of tumor cells
    作者: Lin, TC;Lin, FH;Lin, JC
    貢獻者: Division of Medical Engineering Research
    摘要: Hyperthermia has been reported to be an effective cancer treatment modality, as tumor cells are moretemperature-sensitive than their normal counterparts. Since the ambient temperature can be increasedby placing magnetic nanoparticles in an alternating magnetic field it has become of interest to incorpo-rate these magnetic nanoparticles into biodegradable nanofibers for possible endoscopic hyperthermiatreatment of malignant tumors. In this preliminary investigation we have explored various characteris-tics of biodegradable electrospun chitosan nanofibers containing magnetic nanoparticles prepared by dif-ferent methods. These methods included: (1) E-CHS-Fe 3 O 4 , with electrospun chitosan nanofibers directlyimmersed in a magnetic nanoparticle solution; (2) E-CHS-Fe2+, with the electrospun chitosan nanofibersinitially immersed in Fe+2/Fe+3solution, followed by chemical co-precipitation of the magnetic nanopar-ticles. The morphology and crystalline phase of the magnetic electrospun nanofiber matrices were deter-mined by scanning electron microscopy, transmission electron microscopy, selected area electrondiffraction, and X-ray diffraction spectroscopy. The magnetic characteristics were measured using asuperconducting quantum interference device. The heating properties of these magnetic electrospunnanofiber matrices in an alternating magnetic field were investigated at a frequency of 750 kHz and mag-netic intensity of 6.4 kW. In vitro cell incubation experiments indicated that these magnetic electrospunnanofiber matrices are non-cytotoxic and can effectively reduce tumor cell proliferation upon applicationof a magnetic field.
    日期: 2012-07
    關聯: Acta Biomaterialia. 2012 Jul;8(7):2704-2711.
    Link to: http://dx.doi.org/10.1016/j.actbio.2012.03.045
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1742-7061&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000306442400029
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84861603069
    顯示於類別:[林峯輝] 期刊論文

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