國家衛生研究院 NHRI:Item 3990099045/6483
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    题名: The role of human pituitary transforming gene-1 in transcriptional and cytoskeletal regulation of cancer cells
    作者: Liao, YC;Chen, JH
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Human pituitary tumor-transforming gene-1 (hPTTG1) is an oncogene that is expressed at a high level in most tumors, especially in metastatic ones. Accumulating evidence reveals that hPTTG1 is a trancription factor that has transcriptional activity either by directly or indirectly binding to DNA. Furthermore, hPTTG1 has been identified to regulate Rho guanine nucleotide exchange factor-H1 (GEF-H1) directly, by an interaction with microtubules and contributes to cancer progression. GEF-H1 activity is important for RhoA-dependent changes in cell morphology and actin organization. hPTTG1 activates GEF-H1/RhoA signaling to affect cytoskeleton organization, cell motility, cell invasion, and breast cancer metastasis. Thus, hPTTG1 links changes in microtubule integrity to RhoA-dependent regulation of the actin cytoskeleton, and therefore promotes cancer metastasis. The molecular mechanism that links microtubule dynamics to RhoA-GTPases has not, as yet, been elucidated.
    日期: 2012-09
    關聯: Tzu Chi Medical Journal. 2012 Sep;24(3):97-99.
    Link to: http://dx.doi.org/10.1016/j.tcmj.2012.04.006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84867141453
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