國家衛生研究院 NHRI:Item 3990099045/6491
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    题名: Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life
    作者: Wang, DL;Liu, X;Zhou, Y;Xie, HH;Hong, XM;Tsai, HJ;Wang, GY;Liu, R;Wang, XB
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Prenatal development and early childhood are critical periods for establishing the tissue-specific epigenome, and may have a profound impact on health and disease in later life. However, epigenomic profiles at birth and in early childhood remain largely unexplored. The focus of this report is to examine the individual variation and longitudinal pattern of genome-wide DNA methylation levels from birth through the first two years of life in 105 Black children (59 males and 46 females) enrolled at the Boston Medical Center. We performed epigenomic mapping of cord blood at birth and venous blood samples from the same set of children within the first two years of life using Illumina Infinium Humanmethylation27 BeadChip. We observed a wide range of inter-individual variations in genome-wide methylation at each time point including lower levels at CpG islands, TSS200, 5' UTR and 1st Exon locations, but significantly higher levels in CpG shores, shelves, TSS1500, gene body and 3' UTR. We identified CpG sites with significant intra-individual longitudinal changes in the first two years of life throughout the genome. Specifically, we identified 159 CpG sites in males and 149 CpG sites in females with significant longitudinal changes defined by both statistical significance and magnitude of changes. These significant CpG sites appeared to be located within genes with important biological functions including immunity and inflammation. Further studies are needed to replicate our findings, including analysis by specific cell types, and link those individual variations and longitudinal changes with specific health outcomes in early childhood and later life.
    日期: 2012-06
    關聯: Epigenetics. 2012 Jun;7(6):594-605.
    Link to: http://dx.doi.org/10.4161/epi.20117
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1559-2294&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000304973700009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84861926807
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