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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6492


    Title: UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients
    Authors: Tian, JN;Ho, IK;Tsou, HH;Fang, CP;Hsiao, CF;Chen, CH;Tan, HK;Lin, L;Wu, CS;Su, LW;Huang, CL;Yang, YH;Liu, ML;Chen, YT;Liu, SC;Hsu, YT;Kuo, HW;Liu, CT;Yang, YT;Chen, A;Shih, YH;Liu, YL
    Contributors: Division of Mental Health and Addiction Medicine;Division of Biostatistics and Bioinformatics;Division of Clinical Trial Statistics
    Abstract: Aim: To test whether the genetic polymorphisms within the gene encoding the UGT2B7 gene may have an impact on methadone treatment. Materials & methods: Twelve SNPs in UGT2B7 were selected. 366 methadone maintenance treatment patients in Taiwan were recruited and genotyped. Results: In a genotype recessive model, rs6600879, rs6600880, rs4554144, rs11940316, rs7438135, rs7662029, rs7668258, rs7439366, rs4292394 and rs6600893 showed significant associations with severity of withdrawal symptoms (permutation p < 0.002), pupil size (permutation p < 0.048) and tremor (permutation p < 0.008). Haplotypes of GATCAGCCGC and CTCTGATTCT were significantly associated with pupil size score and tremor score (p < 0.034). Conclusion: These results suggest that SNPs of the UGT2B7 gene may play important roles in opiate withdrawal symptoms.
    Date: 2012-06
    Relation: Pharmacogenomics. 2012 Jun;13(8):879-888.
    Link to: http://dx.doi.org/10.2217/pgs.12.69
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1462-2416&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000305380200013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84862020111
    Appears in Collections:[劉玉麗] 期刊論文
    [蕭金福] 期刊論文
    [鄒小蕙] 期刊論文

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