國家衛生研究院 NHRI:Item 3990099045/6503
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    题名: Using recombinant DNA technology for the development of live-attenuated dengue vaccines
    作者: Lee, HC;Butler, M;Wu, SC
    贡献者: Division of Vaccine Research and Development
    摘要: Dramatic increases in dengue (DEN) incidence and disease severity have been reported, in great part due to the geographic expansion of . Aedes aegypti and . Aedes albopictus mosquitoes. One result is the expanded co-circulation of all dengue 1-4 serotype viruses (DENV) in urban areas worldwide, especially in South and South-East Asia, and South America. DEN disease severity ranges from asymptomatic infections to febrile dengue fevers (DF) to life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). There is an urgent need for a safe and effective tetravalent DEN vaccine. Several live attenuated, tetravalent DEN vaccine candidates have been generated by recombinant DNA technology; these candidates are capable of providing immunity to all four DENV serotypes. In this paper we review (a) recombinant live-attenuated DEN vaccine candidates in terms of deletion, antigen chimerization, and the introduction of adaptive mutations; (b) strategies for improving tetravalent vaccine attenuation; and (c) live-attenuated DENV vaccine development.
    日期: 2012-07-15
    關聯: Enzyme and Microbial Technology. 2012 Jul 15;51(2):67-72.
    Link to: http://dx.doi.org/10.1016/j.enzmictec.2012.05.005
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0141-0229&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000306041100001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84861720279
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