國家衛生研究院 NHRI:Item 3990099045/6542
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    题名: A persistent level of Cisd2 extends healthy lifespan and delays aging in mice
    作者: Wu, CY;Chen, YF;Wang, CH;Kao, CH;Zhuang, HW;Chen, CC;Chen, LK;Kirby, R;Wei, YH;Tsai, SF;Tsai, TF
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: The CISD2 gene, which is an evolutionarily conserved novel gene, encodes a transmembrane protein primarily associated with the mitochondrial outer membrane. Significantly, the CISD2 gene is located within the candidate region on chromosome 4q where a genetic component for human longevity has been mapped. Previously, we have shown that Cisd2 deficiency shortens lifespan resulting in premature aging in mice. Additionally, an age-dependent decrease in Cisd2 expression has been detected during normal aging. In this study, we demonstrate that a persistent level of Cisd2 achieved by transgenic expression in mice extends their median and maximum lifespan without any apparent deleterious side effects. Cisd2 also ameliorates age-associated degeneration of the skin, skeletal muscles and neurons. Moreover, Cisd2 protects mitochondria from age-associated damage and functional decline as well as attenuating the age-associated reduction in whole-body energy metabolism. These results suggest that Cisd2 is a fundamentally important regulator of lifespan and provide an experimental basis for exploring the candidacy of CISD2 in human longevity.
    日期: 2012-09
    關聯: Human Molecular Genetics. 2012 Sep;21(8):3956-3968.
    Link to: http://dx.doi.org/10.1093/hmg/dds210
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0964-6906&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000308230800002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84865739533
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