國家衛生研究院 NHRI:Item 3990099045/6546
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    题名: Identification of porcine rotavirus-like genotype P[6] strains in Taiwanese children
    作者: Hwang, KP;Wu, FT;Bányai, K;Wu, HS;Yang, DCF;Huang, YC;Lin, JS;Hsiung, CA;Huang, JC;Jiang, B;Gentsch, JR
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: The molecular characterization of genotype P [ 6 ] rotavirus strains collected from children admitted to hospital with acute dehydrating diarrhoea during a 6-year surveillance period in Taiwan is described in this study. In total, three G4P [ 6 ] strains, one G5P [ 6 ] and one G12P [ 6 ] were characterized by sequencing and phylogenetic analysis of the VP4, VP7, VP6 and NSP4 genes. Whilst all four genes of the single Taiwanese G12P [ 6 ] strain clustered with the respective genes of globally common human rotavirus strains, the G4 and G5 strains showed remarkable similarities to porcine rotavirus strains and putative porcine-origin human P [ 19 ] strains reported previously from Taiwan. The overall proportion of porcine rotavirus-like strains in Taiwan remains around 1 % among hospitalized children; however, the circulation and sporadic transmission of these heterotypic strains from pigs to humans could pose a public-health concern. Therefore, continuation of strain monitoring is needed in the vaccine era to detect any possible vaccine breakthrough events associated with the introduction of such heterologous rotavirus strains.
    日期: 2012-07
    關聯: Journal of Medical Microbiology. 2012 Jul;61(PT 7):990-997.
    Link to: http://dx.doi.org/10.1099/jmm.0.042499-0
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2615&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000307206700015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84862685218
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