國家衛生研究院 NHRI:Item 3990099045/6594
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    题名: Nanovector-based therapies in advanced pancreatic cancer
    作者: Tsai, CS;Park, JW;Chen, LT
    贡献者: National Institute of Cancer Research
    摘要: Systemic therapy for advanced pancreatic cancer has been largely disappointing owing to the unfavorable pharmacokinetic profile and poor penetration of current chemotherapeutic agents ,as well as the fragile patient population with compromised tolerance to toxic chemotherapies. Nanovectors can provide passive drug delivery through abnormal tumor neo-vasculature microanatomy or active targeting via binding to receptors or macromolecules associated with the tumor. In such a manner, nanovector-based therapy may not only modulate the pharmacokinetics and therapeutic index of chemotherapeutic agents but also provide new treatment options in patients with advanced pancreatic cancer. In this article, we present the rationale and currently available clinical results of nanovector-based therapies to highlight the potential use of this class of agent in patients with advanced pancreatic cancer.
    日期: 2011-09
    關聯: Journal of Gastrointestinal Oncology. 2011 Sep;2(3):185-194.
    Link to: http://dx.doi.org/10.3978/j.issn.2078-6891.2011.034
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2078-6891&DestApp=IC2JCR
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