國家衛生研究院 NHRI:Item 3990099045/6630
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    题名: Determinants of exon-level evolutionary rates in arabidopsis species
    作者: Wu, GCT;Chen, FC
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: What causes the variations in evolutionary rates is fundamental to molecular evolution. However, in plants, the causes of within-gene evolutionary rate variations remain underexplored. Here we use the principal component regression to examine the contributions of eleven exon features to the within-gene variations in nonsynonymous substitution rate (d N), synonymous substitution rate (d S), and the d N/d S ratio in Arabidopsis species. We demonstrate that exon features related to protein structural-functional constraints and mRNA splicing account for the largest proportions of within-gene variations in d N/d S and d N. Meanwhile, for d S, a combination of expression level, exon length, and structural-functional features explains the largest proportion of within-gene variances. Our results suggest that the determinants of within-gene variations differ from those of between-gene variations in evolutionary rates. Furthermore, the relative importance of different exon features also differs between plants and animals. Our study thus may shed a new light on the evolution of plant genes.
    日期: 2012-07-04
    關聯: Evolutionary Bioinformatics. 2012 Jul 04;2012(8):389-415.
    Link to: http://dx.doi.org/10.4137/ebo.s9743
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1176-9343&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000306642700001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864254282
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