國家衛生研究院 NHRI:Item 3990099045/6641
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    題名: Imaging cells and sub-cellular structures with ultrahigh resolution full-field X-ray microscopy
    作者: Chien, CC;Tseng, PY;Chen, HH;Hua, TE;Chen, ST;Chen, YY;Leng, WH;Wang, CH;Hwu, Y;Yin, GC;Liang, KS;Chen, FR;Chu, YS;Yeh, HI;Yang, YC;Yang, CS;Zhang, GL;Je, JH;Margaritondo, G
    貢獻者: Center for Nanomedicine Research
    摘要: Our experimental results demonstrate that full-field hard-X-ray microscopy is finally able to investigate the internal structure of cells in tissues. This result was made possible by three main factors: the use of a coherent (synchrotron) source of X-rays, the exploitation of contrast mechanisms based on the real part of the refractive index and the magnification provided by high-resolution Fresnel zone-plate objectives. We specifically obtained high-quality microradiographs of human and mouse cells with 29nm Rayleigh spatial resolution and verified that tomographic reconstruction could be implemented with a final resolution level suitable for subcellular features. We also demonstrated that a phase retrieval method based on a wave propagation algorithm could yield good subcellular images starting from a series of defocused microradiographs. The concluding discussion compares cellular and subcellular hard-X-ray microradiology with other techniques and evaluates its potential impact on biomedical research.
    日期: 2013-05
    關聯: Biotechnology Advances. 2013 May;31(3):375-386.
    Link to: http://dx.doi.org/10.1016/j.biotechadv.2012.04.005
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0734-9750&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000317441900004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84865489036
    顯示於類別:[楊重熙] 期刊論文

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