國家衛生研究院 NHRI:Item 3990099045/6642

NHRI > Institute of Biomedical Engineering and Nanomedicine > Chung-Shi Yang > Periodical Articles > Item 3990099045/6642

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6642

Title:	Chemical auxiliary-free polymerization yielding non-linear PEG for protein-resistant application
Authors:	Lin, FS;Chien, CT;Chiu, WC;Lin, SY;Tseng, FG;Hwu, Y;Yang, CS
Contributors:	Center for Nanomedicine Research
Abstract:	Current polymerization methods require the use of initiators or catalysts as auxiliaries to produce free radicals and then facilitate the chain propagation. However, these residual auxiliaries may affect polymer functions and cause toxicity, therefore, a time-consuming purification process is essential. Recently, synchrotron light has been established for generation of radicals in water without catalysts and initiators for polymerization. In this study, we used intensive synchrotron light as a potential tool to synthesize non-linear polyethylene glycol (NLPEG) which exhibits excellent protein-resistant property as compared to linear PEG (LPEG) on the surface. This novel synthesis concept provides an opportunity to produce NLPEG in a very short time (5 min) without employing various chemicals (pollutants) and with minimum environmental concern.
Date:	2012-06
Relation:	RSC Advances. 2012 Jun;2(18):7174-7179.
Link to:	http://dx.doi.org/10.1039/C2RA20117H
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2046-2069&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000306946500025
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864493030
Appears in Collections:	[Chung-Shi Yang] Periodical Articles [Shu-Yi Lin] Periodical Articles

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