國家衛生研究院 NHRI:Item 3990099045/6649

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6649

Title:	Incidence rates of enterovirus 71 infections in young children in Taiwan, 2008–09
Authors:	Lee, MS;Chiang, PS;Luo, ST;Huang, ML;Liou, GY;Tsao, KC;Lin, TY
Contributors:	Division of Infectious Diseases
Abstract:	Background: Enterovirus 71 (EV71) is causing life-threatening outbreaks in young children in tropical Asia. In Taiwan and other tropical Asian countries, although nationwide EV71 epidemics occur cyclically, age-specific incidence rates of EV71 infections that are critical to estimate disease burden and design vaccine trials are not clear. A nationwide EV71 epidemic occurred in 2008–09 in Taiwan, which provided a unique opportunity to estimate age-specific incidence rates of EV71 infections. Methods: We prospectively recruited 749 healthy neonates and conducted follow-ups from June 2006 to December 2009. Sera were obtained from participants at 0, 6, 12, 24, and 36 months of age for measuring EV71 neutralizing antibody titers. If the participants developed suspected enterovirus illnesses, throat swabs were collected for virus isolation. Results: We detected 28 EV71 infections including 20 symptomatic and 8 asymptomatic infections. Age-specific incidence rates of EV71 infection increased from 1.71 per 100 person-years at 0–6 months of age to 4.09, 5.74, and 4.97 per 100 person-years at 7–12, 13–24, and 25–36 months of age, respectively. Cumulative incidence rate was 15.15 per 100 persons by 36 months of age, respectively. Conclusion: Risk of EV71 infections in Taiwan increased after 6 months of age during EV71 epidemics. The cumulative incidence rate was 15% by 36 months of age, and 29% of EV71 infections were asymptomatic in young children. These parameters can be further employed to estimate disease burden and design vaccine efficacy trials.
Date:	2012-06
Relation:	International Journal of Infectious Diseases. 2012 Jun;16(Suppl. 1):e264.
Link to:	http://dx.doi.org/10.1016/j.ijid.2012.05.910
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1201-9712&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000308353101232
Appears in Collections:	[Min-Shi Lee] Conference Papers/Meeting Abstract

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