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http://ir.nhri.org.tw/handle/3990099045/6652
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| Title: | Epidemiology and staphylococcal cassette chromosome mec typing of methicillin-resistant Staphylococcus aureus isolates in Taiwan: A multicenter study |
| Authors: | Pan, SC;Wang, JT;Lauderdale, TL;Ko, WC;Chen, YS;Liu, JW;Lau, YJ;Wang, LH;Liu, KS;Liao, CH;Lin, SY;Hu, BS;Chang, SC |
| Contributors: | Division of Infectious Diseases |
| Abstract: | Background/Purpose: After community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) was identified, new community-onset, healthcare-associated MRSA (HA-MRSA-CO) infections have been noticed as MRSA infection in patients with community-onset infection who have underlying conditions resulting in frequent exposure to the healthcare system. However, previous studies have not thoroughly investigated whether HA-MRSA-CO has characteristics resembling those of CA-MRSA or hospital-onset, healthcare-associated MRSA (HA-MRSA-HO) infection. Methods: A multicenter, retrospective study was conducted to analyze the clinical and microbiological data of patients with clinical isolates of MRSA from nine hospitals in Taiwan. Results: In total, 203 patients with MRSA isolates, including 27 patients with CA-MRSA (13.3%), 59 with HA-MRSA-CO (29.1%), and 117 with HA-MRSA-HO (57.6%), were studied. Compared to HA-MRSA-HO isolates, the CA-MRSA and HA-MRSA-CO isolates were associated with a higher proportion of skin and soft tissue infections (81.8% and 65.3% vs. 40.5%, p = 0.001 and p = 0.002) as well as lesser rate of resistance to ciprofloxacin (33.3% and 50.9% vs. 74.4%, p < 0.001 and p = 0.002), gentamicin (44.4% and 64.4% vs. 84.6%, p < 0.001 and p = 0.002), and trimethoprim/sulfamethoxazole (33.3% and 42.4% vs. 58.1%, p = 0.02 and p = 0.048), and a lower 30-day all-cause mortality rate (7.4% and 0% vs. 20.9%, p < 0.001). Most of the CA-MRSA isolates were classified as staphylococcal cassette chromosome mec (SCCmec) type VT (11/27, 40.7%), whereas most HA-MRSA-HO isolates were classified as SCCmec type III (66/117, 56.4%). Conclusion: The CA-MRSA, HA-MRSA-CO, and HA-MRSA-HO clinical isolates significantly differed in their clinical presentations and molecular characteristics. |
| Date: | 2014-07 |
| Relation: | Journal of the Formosan Medical Association. 2014 Jul;113(7):409-416. |
| Link to: | http://dx.doi.org/10.1016/j.jfma.2012.05.012 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0929-6646&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000339088000003 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84902796979 |
| Appears in Collections: | [楊采菱] 期刊論文
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| ISI000339088000003.pdf | | 251Kb | Adobe PDF | 980 | View/Open |
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