國家衛生研究院 NHRI:Item 3990099045/6676
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    題名: Arsenic metabolism, lactate dehydrogenase and electrocardiogram abnormality among residents in the arseniasis-endemic areas of southwestern Taiwan
    作者: Liao, Y;Chen, C;Chen, W;Li, W;Chen, HY;Wang, SL
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: Arsenic is a potent but modifiable environmental pollutant that has been linked to the increasing global prevalence of high-mortality in Cardiovascular Disease (CVD) (Navas-Acien et al. 2005); arsenic can be removed from drinking water to reduce related health effects. Lactate dehydrogenase (LDH) is used for the evaluation of acute arsenic toxicity in vivo and in vitro (Petrick et al.2000; Peraza et al. 2003; Saad et al. 2006), but is not validated for the evaluation of long-term, chronic arsenic exposure. Various Electrocardiogram (ECG) abnormalities have been observed among cases of acute arsenic poisoning and individuals exposed to excess arsenic through drinking water (Wang et al. 2007). While both LDH elevation and ECG abnormality were previously used as indicators for acute myocardial infarction in clinical practice, their correlation amongst arsenic-exposed subjects was still unclear. Individual variability in human arsenic metabolism has been reported to be an underlying determinant of individual susceptibility to arsenic-induced disease (U.S. EPA 1988). The present study examines the long-term effect of chronic arsenic exposure on plasma LDH levels and ECG abnormality.
    日期: 2012-07
    關聯: Understanding the Geological and Medical Interface of Arsenic- As 2012: Proceedings of the 4th International Congress on Arsenic in the Environment, 22-27 July 2012, Cairns, Australia. 2012 Jul:155-156.
    Link to: http://www.crcnetbase.com/doi/abs/10.1201/b12522-63
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000393139700055
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864866305
    顯示於類別:[王淑麗] 會議論文/會議摘要
    [李婉芬(2001-2009)] 會議論文/會議摘要

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