國家衛生研究院 NHRI:Item 3990099045/6679
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 859664      在线人数 : 744
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/6679


    题名: Down-regulation of SERPINB13 expression in head and neck squamous cell carcinomas associates with poor clinical outcome
    作者: Leusink, FKJ;Koole, R;Kummer, JA
    贡献者: National Institute of Cancer Research
    摘要: Introduction: Tumorigenesis of head and neck squamous cell carcinomas (HNSCC) is associated with various genetic changes, including loss of heterozygosity (LOH) of chromosome 18q21. This chromosomal region maps a cluster of human intracellular serine protease inhibitors (serpins), including SERPINB13. Down-regulation of SERPINB13 expression in HNSCC has been demonstrated on both mRNA and protein levels. The aim of the present study was to investigate if down-regulated SERPINB13 protein expression in HNSCC correlates with histopathological and clinical parameters of these tumors and with patient survival. Methods: For this purpose we developed SERPINB13-specific antibodies and SERPINB13 expression was studied by immunohistochemistry in a well-defined cohort of 99 HNSCC of the oral cavity and oropharynx. Results: SERPINB13 expression was partially or totally down-regulated in 75% of the HNSCC as compared with endogenous expression in non-neoplastic epithelial cells. LOH of the SERPINB13 gene in these HNSCC was a major cause of the down-regulated SERPINB13 protein expression. Down-regulation of SERPINB13 expression in HNSCC correlated significantly with a poor differentiation grade of the tumors (p = 0.001), the presence of a lymph node metastasis (p = 0.012), and a decreased disease-free (p = 0.033) as well as overall (p = 0.018) survival of the patients. Conclusion: This is the first report demonstrating that downregulation of SERPINB13 protein expression in HNSCC is positively associated with poor clinical outcome. Therefore, SERPINB13 may act as an important protease inhibitor involved in the progression of HNSCC.
    日期: 2009-07
    關聯: Oral Oncology Supplement. 2009 Jul;3(1):73.
    Link to: http://dx.doi.org/10.1016/j.oos.2009.06.134
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000271015100090
    显示于类别:[其他] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    SDO2012082224.pdf38KbAdobe PDF219检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈