國家衛生研究院 NHRI:Item 3990099045/6681
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    題名: Tumor-associated macrophage correlated with angiogenesis and progression of mucoepidermoid carcinoma of salivary glands
    作者: Shieh, YS;Shiah, SG
    貢獻者: National Institute of Cancer Research
    摘要: Background: There is considerable controversy as to whether tumor-associated macrophage (TAM) promote or inhibit tumor progression. Present study examined the clinicopathologic significance of TAM and its association with tumor angiogenesis, cell proliferation and apoptosis in mucoepidermoid carcinoma (MEC). The potential effect of TAM on cancer cells also was investigated. Methods: CD68, CD34, Ki-67, and vascular endothelial growth factor (VEGF)-A immunohistochemical staining and terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) were evaluated in 41 MEC patients. The biologic effect of macrophage on MEC cancer cells was examined in a co-culture system. Results: Proliferation index (PI) and apoptotic index (AI) were 11.7 ± 5.9% and 4.1 ± 2.3% in cancers, respectively. Significant correlation between PI and tumor grade, PI/AI ratio with tumor size and stage were noted. The distribution of intratumoral TAM and microvessel density (MVD) was heterogeneous. TAM count associated strongly with tumor size, grading, and staging of MEC. Higher intratumoral MVD was observed frequently in patients with large, intermediate/high grade, and advanced stages tumors. VEGF-A expression correlated significantly with tumor size and stage. MVD count closely associated with TAM count and VEGF-A expression. While cancer cells were co-cultured with macrophage, increased migration and invasion ability, elevated VEGF-A expression, and enhanced tube-formation of endothelial cells were observed. Conclusion: Our data suggest the tumor-promoting role of TAM in MEC. Furthermore, the TAM, intratumoral MVD, and the PI/AI ratio are potentially useful markers of progression in patients with MEC.
    日期: 2009-07
    關聯: Oral Oncology Supplement. 2009 Jul;3(1):123.
    Link to: http://dx.doi.org/10.1016/j.oos.2009.06.287
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000271015100241
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