國家衛生研究院 NHRI:Item 3990099045/6683
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6683


    Title: Fetal growth and body size genes and risk of childhood acute lymphoblastic leukemia
    Authors: Chokkalingam, AP;Metayer, C;Scelo, G;Chang, JS;Schiffman, J;Urayama, KY;Ma, X;Hansen, HM;Feusner, JH;Barcellos, LF;Wiencke, JK;Wiemels, JL;Buffler, PA
    Contributors: National Institute of Cancer Research
    Abstract: Accumulating evidence suggests that childhood acute lymphoblastic leukemia (ALL) may be initiated in utero or early in the postnatal period. High birth weight (or rapid fetal growth) is associated with risk of ALL, but the mechanisms are not understood. In a population-based epidemiologic study of childhood ALL, we utilized a haplotype- based approach to assess the role of eight genes involved in fetal growth and body size regulation in 377 childhood ALL cases and 448 controls. We found significant haplotype associations with risk of childhood ALL for IGF1 among non-Hispanics and Hispanics together (p = 0.002), for IGF2 among Hispanics (p = 0.040), and for IGF2R among Hispanics and non-Hispanics (p = 0.051 and 0.009, respectively). No haplotype associations were observed for IGF1R or the studied genes involved in body size regulation, including LEP, LEPR, GHRL, and NPY. Our study is the first to identify an association between the genes involved in the IGF axis and risk of childhood ALL. These findings for childhood ALL emphasize the importance of fetal growth, when lymphoid progenitor cells are not yet fully differentiated and therefore more susceptible to malignant transformation. Additional studies are needed to confirm these findings and identify specific causal variants.
    Date: 2012-08-23
    Relation: Cancer Causes and Control. 2012 Aug 23;23(9):1577-1585.
    Link to: http://dx.doi.org/10.1007/s10552-012-0035-6
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0957-5243&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000307401400018
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864869587
    Appears in Collections:[Jeffrey Shu-Ming] Periodical Articles

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