| 2024-11-08 |
Endosomes serve as signaling platforms for RIG-I ubiquitination and activation |
Science Advances. 2024 Nov 08;10(45):Article number eadq0660. |
 |
| 2024-09 |
The role of dual specificity phosphatase 22 (DUSP22) in rheumatoid arthritis: Mechanism and genetic investigations |
Arthritis and Rheumatology. 2024 Sep;76:75-76. |
|
| 2024-06-14 |
DUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling |
Cell Death Discovery. 2024 Jun 14;10:Article number 285. |
|
| 2024-06 |
UHRF1P contributes to IL-17A-mediated systemic lupus erythematosus via UHRF1-MAP4K3 axis |
Journal of Autoimmunity. 2024 Jun;146:Article number 103221. |
|
| 2024-05-01 |
Sequential regulation of Lck K63-ubiquitination and autophosphorylation by the E3 ligase UBR2 and the phosphatase DUSP22 in TCR signaling |
Journal of Immunology. 2024 May 01;212(1, Suppl.):Meeting Abstract 0220_5352. |
|
| 2024-05-01 |
DUSP8 promotes IL-9 transcription by inactivating Pur-alpha leading to asthma and atopic dermatitis |
Journal of Immunology. 2024 May 01;212(1, Suppl.):Meeting Abstract 0608_4827. |
|
| 2024-05-01 |
Machine learning reveals UHRF-X as a biomarker for systemic lupus erythematosus and an antagonistic protein against UHRF1 E3 ligase |
Journal of Immunology. 2024 May 01;212(1, Suppl.):Meeting Abstract 020-5291. |
|
| 2024-03-27 |
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck |
Journal of Biomedical Science. 2024 Mar 27;31:Article number 33. |
|
| 2024-01-15 |
The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling |
Nature Communications. 2024 Jan 15;15:Article number 532. |
|
| 2023-12-05 |
Dual-specificity phosphatase 6 deficiency attenuates arterial-injury-induced intimal hyperplasia in mice |
International Journal of Molecular Sciences. 2023 Dec 05;24(24):Article number 17136. |
|
| 2023-11-01 |
DUSP8 induces TGF-beta–stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-Alpha |
Journal of Clinical Investigation. 2023 Nov 01;133(21):Article number e166269. |
|
| 2023-08-22 |
ACE2 in chronic disease and COVID-19: Gene regulation and post-translational modification |
Journal of Biomedical Science. 2023 Aug 22;30:Article number 71. |
|
| 2023-06-11 |
作為用於自體免疫疾病及IL-17 相關疾病之生物標記及治療標靶之AhR-ROR-γt 複合體 |
TWI804669/2023-06-11 |
|
| 2023-06 |
Hematopoietic progenitor kinase 1 inhibits the development and progression of pancreatic intraepithelial neoplasia |
Journal of Clinical Investigation. 2023 Jun 15;133(12):Article number e163873. |
|
| 2023-05-01 |
DUSP8 induces TGF-Beta-stimulated IL-9 transcription and Th9-mediated immune responses by inactivating a transcriptional repressor |
Journal of Immunology. 2023 May 01;210(Suppl. 1):Abstract number 243.04. |
|
| 2023-04-22 |
DUSP6 deficiency attenuates neurodegeneration after global cerebral ischemia |
International Journal of Molecular Sciences. 2023 Apr 22;24(9):Article number 7690. |
|
| 2023-02-10 |
Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis |
BMC Medicine. 2023 Feb 10;21:Article number 46. |
|
| 2022-07-27 |
SARS-CoV-2 spike protein enhances MAP4K3/GLK-induced ACE2 stability in COVID-19 |
EMBO Molecular Medicine. 2022 Jul 27:Article number e15904. |
|
| 2022-07-18 |
MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKK beta and inducing IKK beta-mediated FoxO1 nuclear export and Foxp3 downregulation |
Theranostics. 2022 Jul 18;12(12):5744-5760. |
|
| 2022-06-15 |
DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction |
Journal of Biomedical Science. 2022 Jun 15;29:Article number 40. |
|
| 2022-06-14 |
AhR-ROR-γt complex as a biomarker and therapeutic target for autoimmune disease and IL-17A-associated disease |
US11360080/2022-06-14 |
|
| 2022-02-18 |
Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice |
iScience. 2022 Feb 18;25(2):Article number 103738. |
|
| 2022-02 |
Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus |
Annals of the Rheumatic Diseases. 2022 Feb;81(2):243-254. |
|
| 2022-01 |
Induction of interferon-gamma and tissue inflammation by overexpression of eosinophil cationic protein in T cells and exosomes |
Arthritis and Rheumatology. 2022 Jan;74(1):92-104. |
|
| 2021-11-23 |
Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice |
Cell Reports. 2021 Nov 23;37(8):Article number 110016. |
|
| 2021-10-25 |
BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus |
Theranostics. 2021 Oct 25;11(20):9953-9966. |
|
| 2020-10-12 |
Structural insights into the active site formation of dusp22 in n-loop-containing protein tyrosine phosphatases |
International Journal of Molecular Sciences. 2020 Oct 12;21(20):Article number 7515. |
|
| 2020-08-12 |
DUSP11 attenuates lipopolysaccharide-induced macrophage activation by targeting TAK1 |
Journal of Immunology. 2020 Aug 12;205(6):1644-1652. |
|
| 2019-12 |
DUSP22 suppresses prostate cancer proliferation by targeting the EGFR-AR axis |
FASEB Journal. 2019 Dec 5;33(12):14653-14667. |
|
| 2019-11-13 |
MAP4K family kinases and DUSP family phosphatases in T-Cell signaling and systemic lupus erythematosus |
Cells. 2019 Nov 13;8(11):Article number 1433. |
|
| 2019-10-22 |
MAP4K3/GLK in autoimmune disease, cancer and aging |
Journal of Biomedical Science. 2019 Oct 22;26:Article number 82. |
|
| 2019-10 |
AhR-ROR-gammat complex is a therapeutic target for MAP4K3/GLK(high)IL-17A(high) subpopulation of systemic lupus erythematosus |
FASEB Journal. 2019 Oct;3(10):11469-11480. |
|
| 2019-10 |
MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1 |
Cancer Research. 2019 Oct;79(19):4978-4993. |
|
| 2019-07 |
PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency |
Cell Death and Differentiation. 2019 Jul;26 (7):1221-1234. |
|
| 2019-05-30 |
Regulation of Dual-Specificity Phosphatase (DUSP) ubiquitination and protein stability |
International Journal of Molecular Sciences. 2019 May 30;20(11):Article number 2668. |
|
| 2019-05 |
MAP4K3/GLK-induced AhR-RORyt complex is a novel therapeutic target for GLIC(high)IL-17A(high) subpopulation of SLE patients |
Journal of Immunology. 2019 May;202(1, Suppl. S):Meeting Abstract 132.2. |
|
| 2019-05 |
T-cell signaling in Th17-mediated inflammation |
Journal of Immunology. 2019 May;202(1, Suppl. S):Meeting Abstract 124.7. |
|
| 2019-05 |
Control of mucosal barrier functions and gut microbiome homeostasis by DUSP6 in colitis |
Journal of Immunology. 2019 May;202(1, Suppl. S):Meeting Abstract 191.8. |
|
| 2019-04 |
MAP4K4 inhibition promotes survival of human stem cell-derived cardiomyocytes and reduces infarct size in vivo |
Cell Stem Cell. 2019 Apr;24(4):579-591.e12. |
|
| 2018-12 |
RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell |
Biochimica et Biophysica Acta-Molecular Cell Research. 2018 Feb;1865(2):259-272. |
|
| 2018-12 |
Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation |
FASEB Journal. 2018 Dec;32(12):6760-6770. |
|
| 2018-12 |
Induction of TRAF2-mediated DUSP14/MKP6 ubiquitination by PRMT5-mediated arginine methylation |
Molecular Biology of the Cell. 2018 Dec;29(26):Abstract number P1574. |
|
| 2018-09-12 |
GLK-IKKbeta signaling induces dimerization and translocation of the AhR-RORgammat complex in IL-17A induction and autoimmune disease |
Science Advances. 2018 Sep 12;4(9):Article number eaat5401. |
|
| 2018-09-06 |
RBM4A-SRSF3-MAP4K4 splicing cascade constitutes a molecular mechanism for regulating brown adipogenesis |
International Journal of Molecular Sciences. 2018 Sep 6;19(9):Article number 2646. |
|
| 2018-08-21 |
DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation |
Proceedings of the National Academy of Sciences of the United States of America. 2018 Aug 21;115(34):E8027-E8036. |
|
| 2018-06-15 |
GLK介在疾患の治療薬同定方法 |
JP6351503/2018-06-15 |
|
| 2018 |
MAP4K3 (GLK) |
Encyclopedia of Signaling Molecules. 2018 :2947-2951. |
|
| 2017-11 |
Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration |
Oncogene. 2017 Nov;36(47):6509-6517. |
|
| 2017-09-22 |
MAP4K3作为自体免疫疾病、癌症、发炎及IL‑17相关疾病的生物标记及治疗标的 |
CN103827310/2017-09-22 |
|
| 2017-07-19 |
MAP4k3 as a biomarker and therapetic target for autoimmune disease, cancer, inflammation and il-17- associated disease |
EP2732045/2017-07-19 |
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