國家衛生研究院 NHRI:Item 3990099045/6727
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    题名: Design and analysis issues of multiregional clinical trials with different regional primary endpoints
    作者: Tsou, HH;Tsong, Y;Chang, WJ;Dong, X;Hsiao, CF
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: One of the challenges of multiregional drug development program is to design and analyze a multiple regional clinical trial with the objective being to satisfy different regional requirements on primary endpoints. Considered in this article is a multiregional clinical trial (MRCT) designed to test for two primary endpoints. Data of a regular fixed-size well-controlled parallel arm trial are used to test for two null hypotheses in terms of two distinct yet correlated endpoints. The two hypotheses may be tested sequentially or simultaneously. Depending on the structure of the hypotheses to be tested and the understanding of type I error rate control, various scenarios of type I error rate adjustments may be applied. Furthermore, for the objective of getting approval from regional authorities for different primary endpoints, various sample size and power determinations may be applied. In this article, comparisons of different approaches are discussed systematically.
    日期: 2012-09
    關聯: Journal of Biopharmaceutical Statistics. 2012 Sep;22(5):1051-1059.
    Link to: http://dx.doi.org/10.1080/10543406.2012.701586
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1054-3406&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000308983200014
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84866294832
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