國家衛生研究院 NHRI:Item 3990099045/6735
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    题名: Regulation of PKC-theta function by phosphorylation in T cell receptor signaling
    其它题名: Regulation of PKC-θ function by phosphorylation in T cell receptor signaling
    作者: Wang, X;Chuang, HC;Li, JP;Tan, TH
    贡献者: Immunology Research Center
    摘要: Protein kinase C (PKC)-θ is a serine/threonine kinase belonging to the calcium-independent novel PKC subfamily; its expression is restricted to certain tissues and cell types, including T cells. The signals delivered from T cell receptor (TCR) and CD28 costimulatory molecules trigger PKC-θ catalytic activation and membrane translocation to the immune logical synapse, leading to activation of NF-κB, AP-1, and NF-AT.These transcription factors are important forT cell survival, activation, and differentiation. Phosphorylation of PKC-θ at multiple Ser/Thr/Tyr residues is induced inT cells duringTCR signaling. Some phosphorylation sites play critical roles in the regulation of PKC-θ function and downstream signaling. The regulation mechanisms for PKC-θ phosphorylation sites are now being revealed. In this review, we discuss the current understanding of the regulation of PKC-θ function by phosphorylation duringTCR signaling.
    日期: 2012-07
    關聯: Frontiers in Immunology. 2012 Jul;3:Article number 197.
    Link to: http://dx.doi.org/10.3389/fimmu.2012.00197
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1664-3224&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000209501300193
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84874219989
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