國家衛生研究院 NHRI:Item 3990099045/6749
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    題名: Dissemination of multidrug-resistant Acinetobacter baumannii carrying BlaOxA-23 from hospitals in central Taiwan
    作者: Lee, MH;Chen, TL;Lee, YT;Huang, L;Kuo, SC;Yu, KW;Hsueh, PR;Dou, HY;Su, IJ;Fung, CP
    貢獻者: Division of Infectious Diseases
    摘要: Background: Imipenem-resistant Acinetobacter baumannii (IRAB) poses a great threat to healthcare systems. Production of carbapenem-hydrolyzing class D b-lactamases (CHDLs) is the major mechanism for imipenem resistance. In this study, we found a high prevalence of IRAB carrying a gene encoding CHDL, blaOxA-23, in central Taiwan and elucidated the molecular characteristics and possible mechanisms of the spread of these isolates. Methods: During 2007, we collected 291 nonrepetitive A baumannii isolates from 10 teaching hospitals in Taiwan. The antimicrobial susceptibility of the isolates was determined by agar dilution or Etest. The genes encoding carbapenemase and related structure were detected by polymerase chain reaction mapping and sequencing, and the clonal relationship of the isolates was analyzed by pulsed-field gel electrophoresis. Plasmid localization of blaOxA-23 was determined by extraction of plasmid with commercial kit and Southern blot analysis. Results: Among 142 IRAB isolates, 30 harbored the blaOxA-23. The prevalence of IRAB with blaOxA-23 was highest in central Taiwan compared to other areas [24.8% (27/109) vs. 1.6% (3/182); p < 0.001]. These IRAB with blaOxA-23 were also resistant to other antimicrobial agents, except colistin. The PCR methods showed the presence of blaOxA-51 in all isolates.
    日期: 2013-12
    關聯: Journal of Microbiology, Immunology and Infection. 2013 Dec;46(6):419-424.
    Link to: http://dx.doi.org/10.1016/j.jmii.2012.08.006
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1684-1182&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000329598800003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84890126531
    顯示於類別:[蘇益仁(2002-2015)] 期刊論文
    [杜鴻運] 期刊論文
    [郭書辰] 期刊論文

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