國家衛生研究院 NHRI:Item 3990099045/6763
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 852398      在线人数 : 1588
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/6763


    题名: Psychotropic drugs and risk of motor vehicle accidents: A population-based case-control study
    作者: Chang, CM;Wu, ECH;Chen, CY;Wu, KY;Liang, HY;Chau, YL;Wu, CS;Lin, KM;Tsai, HJ
    贡献者: Division of Mental Health and Addiction Medicine;Division of Biostatistics and Bioinformatics
    摘要: Aim To comprehensively examine the relationship between exposure to four classes of psychotropic drugs including antipsychotics, antidepressants, benzodiazepines (BZDs) and Z-drugs, and motor vehicle accidents (MVAs). Methods The authors conducted a matched case-control study of 5,183 subjects with MVAs and 31,093 matched controls, identified from the claims records of outpatient service visits during the period from 2000 to2009. Inclusion criteria were defined as subjects aged equal to or more than 18 years and involved in MVAs. Conditional logistic regressions with covariates adjustment (including: urbanity, psychiatric and non-psychiatric outpatient visits, and Charlson comorbidity score) were applied to examine the effect of four classes of psychotropic drugs on MVAs. Results Significant increased risk of MVAs was found in subjects taking antidepressants within one month (adjusted odds ratio (AOR)=1.73, 95% confidence interval (CI)=1.34-2.22), one week (AOR=1.71, 95%CI=1.29-2.26), and one day (AOR=1.70, 95%CI=1.26-2.29) before MVAs occurred. Similar results were observed in subjects taking benzodiazepines (BZDs) (AOR=1.56, 95%CI=1.38-1.75 for one month; AOR=1.64, 95%CI=1.43-1.88 for one week, and AOR=1.62, 95%CI=1.39-1.88 for one day) and Z-drugs (AOR=1.42, 95%CI=1.14-1.76 for one month, AOR=1.37, 95%CI=1.06-1.75 for one week, AOR=1.34, 95%CI=1.03-1.75 for one day), but not antipsychotics. Moreover, significant dose effects of antidepressants (equal to or more than 0.6-1.0 DDD), BZDs (equal to or more than 0.1-0.5 DDD), and Z-drugs (more than 1 DDD) were observed, respectively, on the risk of experiencing an MVA. Conclusions Taken together, subjects taking antidepressants, BZDs and Z-drugs, separately, should be particularly cautioned for their increasing risk of MVAs.
    日期: 2013-04
    關聯: British Journal of Clinical Pharmacology. 2013 Apr;75(4):1125-1133.
    Link to: http://dx.doi.org/10.1111/j.1365-2125.2012.04410.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0306-5251&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000316326200026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84875072275
    显示于类别:[林克明(2004-2009)] 期刊論文
    [蔡慧如] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    WIL2012092005.pdf737KbAdobe PDF695检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈