國家衛生研究院 NHRI:Item 3990099045/6765
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    题名: Statin use and the risk of bladder cancer: A population-based case-control study
    作者: Kuo, CC;Chiu, HF;Lee, IM;Kuo, HW;Lee, CT;Yang, CY
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Objective: The aim of this study was to investigate whether the use of statins is associated with bladder cancer risk. Methods: The authors conducted a population-based case-control study in Taiwan. Cases consisted of all patients who were aged 50 years and older and had a first-time diagnosis of bladder cancer, for the period between 2004 and 2010. The controls were matched to cases by age, sex and index date. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by using multiple logistic regression. Results: The authors examined 325 bladder cancer cases and 1300 controls. The unadjusted ORs for any statin prescription was 0.94 (95% CI 0.70 - 1.28) and the adjusted OR was 0.88 (95% CI 0.61 - 1.25). Compared with no use of statins, the adjusted ORs were 0.72 (95% CI 0.40 - 1.28) for the group having been prescribed statins with cumulative defined daily dose (DDDs) below 56 DDDs, 0.81 (95% CI 0.46 - 1.43) for the group with cumulative dose between 56 DDDs and 196 DDDs, and 1.11 (95% CI 0.67 - 1.85) for the group with cumulative statin use of 196 DDDs or more. Conclusions: The present data do not provide evidence to support either beneficial or harmful associations between statin use and bladder cancer risk.
    日期: 2012-09
    關聯: Expert Opinion on Drug Safety. 2012 Sep;11(5):733-738.
    Link to: http://dx.doi.org/10.1517/14740338.2012.712960
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1474-0338&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000307997500006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84865528723
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