We formalize a theory to help explore the effect of conformational fluctuation on the energy landscape evolution of single-molecule protein. Using this formalization, we investigate the photon emission from single photoactivated fluorescent protein. A bimodal regulation on the energy landscape evolution was discovered, and its origin was attributed to slow conformational fluctuations of the protein matrix.
Date:
2012-08-31
Relation:
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 2012 Aug 31;86(2):Article number 021925.
