國家衛生研究院 NHRI:Item 3990099045/6803
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6803


    Title: A pilot randomized controlled trial to improve geriatric frailty
    Authors: Chan, DC;Tsou, HH;Yang, RS;Tsauo, JY;Chen, CY;Hsiung, CA;Kuo, K
    Contributors: Division of Health Services and Preventive Medicine;Division of Biostatistics and Bioinformatics;Division of Geriatric Research
    Abstract: BACKGROUND:Few randomized controlled trials (RCTs) report interventions targeting improvement of frailty status as an outcome.METHODS:This RCT enrolled 117 older adults (65-79 years of age) in Toufen, Taiwan who scored 3-6 on The Chinese Canadian Study of Health and Aging Clinical Frailty Scale Telephone Version and then score >=1 on the Cardiovascular Health Study Phenotypic Classification of Frailty (CHS_PCF). With a two by two factorial design, subjects were randomly assigned to interventions (Exercise and nutrition, EN, n = 55 or problem solving therapy, PST, n = 57) or controls (non-EN, n = 62 or non-PST, n = 60). Educational booklets were provided to all. EN group subjects received nutrition consultation and a thrice-weekly exercise-training program while PST group subjects received 6 sessions in 3 month. Subjects were followed at 3, 6, and 12 months. Primary outcome was improvement of the CHS_PCF by at least one category (from pre-frail to robust, or from frail to pre-frail or robust) from baseline assessments. One hundred and one completed final assessments. Intention-to-treat analysis with the generalized estimating equation model was applied with adjustment for time and treatment-by-time interactions.RESULTS:Mean age was 71.4 +/- 3.7 years, with 59% females. Baseline characteristic were generally comparable between groups. EN group subjects had a higher improvement rate on the primary outcome than non-EN group subjects (45% vs 27%, adjusted p = 0.008) at 3 months, but not 6 or 12 months. They also had more increase of serum 25(OH) vitamin D level (4.9 +/- 7.7 vs 1.2 +/- 5.4, p = 0.006) and lower percentage of osteopenia (74% vs 89% p = 0.042) at 12 months. PST group subjects had better improvement (2.7 +/- 6.1 vs 0.2 +/- 6.7, p = 0.035, 6-month) and less deterioration (-3.5 +/- 9.7 vs -7.1 +/- 8.7, p = 0.036, 12-month) of dominant leg extension power than non-PST subjects. Some secondary outcomes were also improved in control groups (non-EN or non-PST). No adverse effects were reported.CONCLUSIONS:The three-month EN intervention resulted in short-term (3-month) frailty status improvement and long-term effect on bone mineral density and serum vitamin D (12-month) among Taiwanese community-dwelling elders. The effect of PST was less pronounce.Trial registrationClinicalTrials.gov: EC0970301
    Date: 2012-09-25
    Relation: BMC Geriatrics. 2012 Sep 25;12(1):Article number 58.
    Link to: http://dx.doi.org/10.1186/1471-2318-12-58
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1471-2318&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000313489500001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84866526558
    Appears in Collections:[Ken-Nan Kuo] Periodical Articles
    [Chao A. Hsiung] Periodical Articles
    [Hsiao-Hui Sophie Tsou] Periodical Articles
    [Ching-Yu Chen(2006-2010)] Periodical Articles

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