國家衛生研究院 NHRI:Item 3990099045/6806

NHRI > Institute of Population Health Sciences > Jaw-Town Lin > Conference Papers/Meeting Abstract > Item 3990099045/6806

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6806

Title:	Long-term risk of recurrent peptic ulcer bleeding in patients with liver cirrhosis: A 10-year nationwide cohort study
Authors:	Lin, JT;Hsu, YC;Chen, TT;Wu, MS;Wu, CY
Contributors:	Division of Health Services and Preventive Medicine
Abstract:	Background: Peptic ulcer bleeding leads to substantial morbidity and mortality in patients with liver cirrhosis, whose long-term risk of recurrent bleeding remains elusive. In order to elucidate the association between cirrhosis and peptic ulcer rebleeding, we conducted this nationwide cohort study by analyzing the Taiwan National Health Insurance Research Database. Methods: From all patients (n=271,030) hospitalized because of peptic ulcer bleeding between January 1997 and December 2006, we identified 9,711 patients with liver cirrhosis and selected 38,844 non-cirrhotic controls matched with 1:4 proportion in age, gender, and use of gastroprotective agents. Cumulative incidences and hazard ratios were analyzed. Results: The cumulative incidences of recurrent bleeding were significantly higher in cirrhotic patients than in controls (1 year: 17.0% vs. 11.9%, 5 year: 36.2% vs. 24.9%, and 10 years: 42.2% vs. 31.0%, all p<0.001). The excessive risk of rebleeding associated with cirrhosis was consistently found in stratified analyses. However, the hazard ratio diminished with age because the rebleeding incidence was high regardless of age in cirrhotic patients, whereas it rose incrementally with age in controls. The multivariate Cox regression analysis verified cirrhosis as an independent risk factor for recurrent peptic ulcer bleeding with an adjusted hazard ratio of 1.43 (95% confidence interval: 1.36-1.50). Conclusion:Liver cirrhosis is independently associated with higher risk of recurrent peptic ulcer bleeding. The high rebleeding rate found in all cirrhotic patients with different demographic characteristics highlights the urgent needs for effective therapies to reduce this long-term risk.
Date:	2012-05
Relation:	Gastroenterology. 2012 May;142(5 Suppl. 1):S503.
Link to:	http://download.journals.elsevierhealth.com/pdfs/journals/0016-5085/PIIS0016508512619271.pdf
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0016-5085&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000306994302607
Appears in Collections:	[Jaw-Town Lin] Conference Papers/Meeting Abstract

Files in This Item:

File	Description	Size	Format
ISI000306994302607.pdf		129Kb	Adobe PDF	699	View/Open

Loading...