國家衛生研究院 NHRI:Item 3990099045/6848
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    题名: Improving bone reconstruction in the rat ulnar nonunion model via controlling human recombinant bone morphogenetic protein-2 release
    作者: Chen, CY;Li, PS;Hsieh, MY;Shen, HH;Lin, YH;Lin, FH;Sun, JS
    贡献者: Division of Medical Engineering Research
    摘要: Introduction: Congenital or acquired bone defects are major problems in orthopedic surgery. In this study, we conjugated a hydrophobic polyester compound, BOX, into the PLGA/PEG thermal hydrogel for control release model. In the past few years, we had already known that BMP-2 plays an important role in bone formation. The aim of this study, we created a model of critical-sized detect and design implants with osteoinductive growth factor for bone remodeling. Materials and Methods: 45 female Wistar rats were assigned into five groups (n = 9), and created a 5-mm segmental bone defect on bilateral ulnas. Through this study, we can validate the efficiency of collagen sponges and BOX hydrogel cooperating with rhBMP-2 on the critical-sized defect healing. Results: Through the data, we demonstrated the efficiency of Collagen/BOX implants combined with BMP-2 has better osteoinductive effect and can promote fracture healing on critical-sized bone defect model. Among HE staining of bone defect sections in these two experimental groups at 4 weeks after surgery demonstrated that there were regenerated bone elements formation, such as endochondral cells, osteoblasts and osteocytes. We found that bone formation at Collagen/BOX group combined with the vascular penetration of new blood vessels into the redeveloped area.
    日期: 2012-09
    關聯: Journal of Tissue Engineering and Regenerative Medicine. 2012 Sep;6(Suppl. 1):19-20.
    Link to: http://dx.doi.org/10.1002/term.1586
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6254&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000308313000071
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