國家衛生研究院 NHRI:Item 3990099045/6856
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 861835      在线人数 : 810
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/6856


    题名: The association between clinical symptomatic hypoglycemia with cardiovascular events in type 2 diabetes: A nested case control study in nation-wide representative population
    作者: Feng, HP;Sung, SH;Yeh, JS;Cheng, HM;Chen, WL;Chuang, SY
    贡献者: Division of Health Services and Preventive Medicine
    摘要: Background: Hypoglycemia was already known to be associated with serious health outcomes. Previous evidences were all derived from clinical trials or inpatient database with other specific admission cause. How is the consequence of those clinically treated type 2 diabetes patients who had hypoglycemia episode experiences is unknown? Methods: The study population was comprised of 76,987 type 2 diabetic mellitus patients identified from the “National Health Insurance Research Database” released by the Taiwan National Health Research Institutes during 2000-2009. We designed a nested case control cohort, which was consistent of hypoglycemic type 2 diabetes patients with randomly selected and matched type 2 diabetes patients without hypoglycemia. We investigated the relationship between hypoglycemia and cardiovascular events including stroke, coronary heart disease, cardiovascular events, and all cause of hospitalization. Results: There were total 2,641 hypoglycemic events (589 defined by inpatient and 2,052 defined by outpatient) from 76,986 type 2 diabetes mellitus patients. The incidence risk of hypoglycemia was 3.43% (2,641/76,986). Women had higher risk of hypoglycemia than men (1.98% vs. 1.45%). Both in the mild and severe hypoglycemia cases have higher percentage of co morbidity, including hypertension, renal diseases, cancer, stroke and heart disease. Hypertension (HR = 1.74; 95%confidence intervals: 1.58-1.92), renal disease (2.96; 2.57-3.40), cancer (2.37; 1.94-2.91), stroke (2.79; 2.35-3.29), and coronary heart disease (1.81; 1.52-2.15) were independently associated with hypoglycemia. Those diabetes patients with hypoglycemia had significantly higher risk of cardiovascular events in clinical treatment periods in multivariate models. Even after propensity score adjusted model,mild and severe hypoglycemia still have around 1.94 (1.71-2.19), 2.23 (2.00-2.49) higher relative risk for CVD and all cause hospitalization respectively. Around 70%of hypoglycemic subjects experienced admission of any cause in the following first year. Conclusion: Symptomatic hypoglycemia, both clinically mild and severe, were associated with an increased risk for cardiovascular and all causes events for hospitalization. The adverse events after hypoglycemia are most frequently occurred in the following first year. Clinically, we should aggressively treat those hypoglycemic episode accompanied type 2 diabetes patients and prevent their immediate and further clinical adverse events.
    日期: 2012-08
    關聯: European Heart Journal. 2012 Aug;33(Suppl. 1):180-181.
    Link to: http://dx.doi.org/10.1093/eurheartj/ehs281
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0195-668X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000308012401610
    显示于类别:[莊紹源] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000308012401610.pdf184KbAdobe PDF561检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈