國家衛生研究院 NHRI:Item 3990099045/6910

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Title:	Thermosensitive hydrogel made of ferulic acid-gelatin and chitosan glycerophosphate
Authors:	Cheng, YH;Yang, SH;Liu, CC;Gefen, A;Lin, FH
Contributors:	Division of Medical Engineering Research
Abstract:	Reactive oxygen species-induced oxidative stress is involved in apoptosis of nucleus pulposus (NP) cells that can alter cellular phenotype and accelerate disc degeneration. Ferulic acid (FA) possesses an excellent antioxidant and anti-inflammatory properties. In the study, we developed the thermosensitive FA-gelatin/chitosan/glycerol phosphate (FA-G/C/GP) hydrogel which was applied as a sustained release system of FA to treat NP cells from the damage caused by oxidative stress. The gelation temperature of the FA-G/C/GP hydrogel was 32.17 ?C. NP cells submitted to oxidative stress promoted by H2O2, and post-treated with FA-G/C/GP exhibited down-regulation of MMP-3 and up-regulation aggrecan and type II collagen in mRNA level. The sulfated-glycosaminoglycan production was increased and the apoptosis was inhibited in the post-treatment group. The results suggest that the thermosensitive FA-G/C/GP hydrogel can treat NP cells from the damage caused by oxidative stress and may apply in minimally invasive surgery for NP regeneration.
Date:	2013-02-15
Relation:	Carbohydrate Polymers. 2013 Feb 15;92(2):1512-1519.
Link to:	http://dx.doi.org/10.1016/j.carbpol.2012.10.074
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0144-8617&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000315616900069
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870326387
Appears in Collections:	[Feng-Huei Lin] Periodical Articles

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