國家衛生研究院 NHRI:Item 3990099045/6936
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 851158      Online Users : 529
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6936


    Title: The evolutionary landscape of the Mycobacterium tuberculosis genome
    Authors: Wang, TC;Chen, FC
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Mycobacterium tuberculosis is one of the most deadly human pathogens. The major mechanism for the adaptations of M. tuberculosis is nucleotide substitution. Previous studies have relied on the nonsynonymous-to-synonymous substitution rate (d(N)/d(S)) ratio as a measurement of selective constraint based on the assumed selective neutrality of synonymous substitutions. However, this assumption has been shown to be untrue in many cases. In this study, we used the substitution rate in intergenic regions (d(i)) of the M. tuberculosis genome as the neutral reference, and conducted a genome-wide profiling for d(i), d(S), and the rate of insertions/deletions (indel rate) as compared with the genome of M. canettii using a 50 Kb sliding window. We demonstrate significant variations in all of the three evolutionary measurements across the M. tuberculosis genome, even for regions in close vicinity. Furthermore, we identified a total of 233 genes with their d(S) deviating significantly from d(i) within the same window. Interestingly, d(S) also varies significantly in some of the windows, indicating drastic changes in mutation rate and/or selection pressure within relatively short distances in the M. tuberculosis genome. Importantly, our results indicate that selection on synonymous substitutions is common in the M. tuberculosis genome. Therefore, the d(N)/d(S) ratio test must be applied carefully for measuring selection pressure on M. tuberculosis genes.
    Date: 2013-04
    Relation: Gene. 2013 Apr;518(1):187-193.
    Link to: http://dx.doi.org/10.1016/j.gene.2012.11.033
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0378-1119&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000316424100026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84875374934
    Appears in Collections:[Feng-Chi Chen] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    PUB23219994.pdf730KbAdobe PDF576View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback