國家衛生研究院 NHRI:Item 3990099045/6967
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    題名: Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund-von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines
    作者: Lee, HY;Lee, LW;Nien, CY;Kuo, CC;Lin, PY;Chang, CY;Chang, JY;Liou, JP
    貢獻者: National Institute of Cancer Research
    摘要: A variety of functionalities were introduced at 2-aroylquinoline's C5 position, which is considered equivalent to C-3′ of the B-ring of CA4, via Suzuki arylation, Sonogashira ethynylation, and Rosenmund-von Braun cyanation. These substitutions are rarely utilized in the modification of 3′-OH of CA4. The resulting products 6 and 7 having cyano and ethynyl groups exhibited comparable antiproliferative and tubulin inhibitory activities to colchicine.
    日期: 2012-12
    關聯: Organic and Biomolecular Chemistry. 2012 Dec;10(48):9593-9600.
    Link to: http://dx.doi.org/10.1039/c2ob26614h
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1477-0520&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000311755100008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870050029
    顯示於類別:[郭靜娟] 期刊論文
    [張俊彥] 期刊論文

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