國家衛生研究院 NHRI:Item 3990099045/6984

NHRI > Institute of Population Health Sciences > Chih-Cheng Hsu > Conference Papers/Meeting Abstract > Item 3990099045/6984

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6984

Title:	Polymorphisms in FADS2 correlated with altered desaturase activity in a type-2 diabetic cohort
Authors:	Huang, PC;Jhang, HR;Hsu, CC;Kothapalli, K;Brenna, T;Huang, MC
Contributors:	Division of Health Services and Preventive Medicine
Abstract:	Recent evidence reveals that single nucleotide polymorphisms (SNP) in fatty acid desaturase 2 (FADS2) is correlated with alteration in blood fatty acid profile in some ethnic groups. We aimed to examine effects of FADS2 (intronic SNP, rs174589 ) on delta6 and delta5 desaturase activities based on ratios of 18:3n-6/18:2n-6 and 20:4n-6/20:3n-6 respectively. In 2008, we cross-sectionally analyzed erythrocyte fatty acids in type 2 diabetic patients (n=702) recruited from the Diabetes Management through Integrated Delivery System (DMIDS) cohort established in Taiwan. Frequencies of rs174589 genotypes GG, GC and CC were 0.739, 0.234 and 0.027 respectively. Levels of hemoglobin A1c in CC genotypes were significantly different from those of GC and GG genotypes. delta6 desaturase activity (18:3n-6/18:2n-6) was significantly reduced in GC (0.005±0.003, p=0.003) and CC (0.004±0.003, p=0.025) than GG genotypes (0.006±0.003). Similarly, delta5 desaturase activity (20:4n-6/20:3n-6) was significantly diminished in C allele carriers than the GG homozygotes (p<0.05). In conclusion, rs174589 in FADS2 is associated with delat6 and delta5 desaturase activities in type 2 diabetes patients and impact of these alterations in fatty acids profiles on clinical parameters warrants further investigation.
Date:	2012-04
Relation:	FASEB Journal. 2012 Apr;26:1016.7.
Link to:	http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/1016.7
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000310711302357
Appears in Collections:	[Chih-Cheng Hsu] Conference Papers/Meeting Abstract

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