國家衛生研究院 NHRI:Item 3990099045/6988
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    题名: Changes of interleukin 6 and N-3 polyunsaturates and kidney function decline in type 2 diabetes
    作者: Chen, PS;Hsu, CC;Jhang, HR;Hwang, SJ;Huang, MC
    贡献者: Division of Health Services and Preventive Medicine
    摘要: Background and aims: Potential modifiable dietary or inflammatory biomarkers may impact the decline estimated glomerular filtration rate (eGFR), but very few has been examined in type 2 diabetes. Methods: Eighty-eight type 2 diabetic adults free of kidney disease who have participated in the Diabetes Management through Integrated Delivery System (DMIDS) cohort were recruited from primary clinics in southern Taiwan and followed for 3 years. An eGFR decline of > 33% was the outcome and interleukin 6 and erythrocyte fatty acids were the modifiable biomarkers examined. Results: Significant (p< 0.05) higher rate of increases in fasting plasma glucose (19% vs. –0.4%), triglycerides (30% vs 3%) and interleukin 6 (IL-6) (126% vs. 106%) were found between subjects with eGFR decline of > 33% than < 33%. Rate of increases in total erythrocyte n-3 polyunsaturates were also marginally different (p=0.05) between the two groups (51.3% vs 81%). In conclusion, rate of elevation of interleukin 6 appears to associate with greater kidney function decline in type 2 diabetes. Identification of dietary strategy to modify IL-6 concentrations may be worth for future investigation.
    日期: 2011-04
    關聯: FASEB Journal. 2011 Apr;25:595.9.
    Link to: http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/595.9
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000310708403256
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