國家衛生研究院 NHRI:Item 3990099045/7030

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7030

Title:	Postoperative antiviral therapy with pegylated interferon plus ribavirin associated with reduced recurrence of hepatitis C virus-related hepatocellular carcinoma
Authors:	Hsu, YC;Lin, JT;Ho, HJ;Wu, MS;Wu, CY
Contributors:	Division of Health Services and Preventive Medicine
Abstract:	Background: Hepatocellular carcinoma (HCC) commonly recurs after surgical resection without effective adjuvant therapy. Pegylated interferon plus ribavirin has been shown efficacious in preventing the development of hepatitis C virus (HCV)-related HCC, but its efficacy in reducing HCC recurrence remains unknown. Objective: We aimed to investigate whether postoperative antiviral therapy reduced recurrence of HCVrelated HCC after resection. Methods: This population-based retrospective cohort study analyzed the Taiwan National Health Insurance Research Database. After screening 17,574 patients undergoing liver surgery for a first-time diagnosis of HCC between October 2003 and December 2008, we identified 893 patients with antiviral-na?ve HCV infection who had curative resection without recurrence within one year. Ninety five eligible patients received postoperative pegylated interferon plus ribavirin (treated cohort), and were matched 1:4 in age, gender, and cirrhosis status with 380 patients using no antiviral agent (untreated cohort). Patients were followed up for HCC recurrence and mortality since one year after surgery. Results: The HCC recurrence rate was significantly lower in the treated than the untreated cohort (32.39% versus 47.69% after 3 years of follow-up, p=0.004). With adjustment for multiple confounders including death occurring prior to HCC recurrence, the recurrence risk was reduced nearly by half (hazard ratio 0.52; 95% CI, 0.34-0.80) among treated patients. Multivariate stratified analyses confirmed antiviral therapy was consistently associated with attenuated risk of HCC recurrence across subgroups. Moreover, mortality was lower in the treated cohort significantly (1.92% vs. 17.68% after 3 years of follow-up, p=0.004). Conclusions: Postoperative pegylated interferon plus ribavirin is associated with reduced recurrence of surgically resected HCV-related HCC.
Date:	2012-10
Relation:	Hepatology. 2012 Oct;56(Suppl. 1):276A.
Link to:	http://dx.doi.org/10.1002/hep.26040
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0270-9139&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000310955601165
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84867585259
Appears in Collections:	[Jaw-Town Lin] Conference Papers/Meeting Abstract

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