國家衛生研究院 NHRI:Item 3990099045/7049

NHRI > National Institute of Infectious Diseases and Vaccinology > Hsin-Wei Chen > Periodical Articles > Item 3990099045/7049

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7049

Title:	A consensus envelope protein domain III can induce neutralizing antibody responses against serotype 2 of dengue virus in non-human primates
Authors:	Chen, HW;Liu, SJ;Li, YS;Liu, HH;Tsai, JP;Chiang, CY;Chen, MY;Hwang, CS;Huang, CC;Hu, HM;Chung, HH;Wu, SH;Chong, P;Leng, CH;Pan, CH
Contributors:	Division of Vaccine Research and Development
Abstract:	We have previously demonstrated that vaccination with a subunit dengue vaccine containing a consensus envelope domain III with aluminum phosphate elicits neutralizing antibodies against all four serotypes of dengue virus in mice. In this study, we evaluated the immunogenicity of the subunit dengue vaccine in nonhuman primates. After vaccination, monkeys that received the subunit vaccine with aluminum phosphate developed a significantly strong and long-lasting antibody response. A specific T cell response with cytokine production was also induced, and this correlated with the antibody response. Additionally, neutralizing antibodies against serotype 2 were detected in two of three monkeys. The increase in serotype-2-specific antibody titers and avidity observed in these two monkeys suggested that a serotype-2-biased antibody response occurs. These data provide evidence that a protective neutralizing antibody response was successfully elicited in non-human primates by the dengue subunit vaccine with aluminum phosphate adjuvant.
Date:	2013-07
Relation:	Archives of Virology. 2013 Jul;158(7):1523-1531.
Link to:	http://dx.doi.org/10.1007/s00705-013-1639-1
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-8608&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000321066600009
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84879695861
Appears in Collections:	[Hsin-Wei Chen] Periodical Articles [Shih-Jen Liu] Periodical Articles [Pele Choi-Sing Chong] Periodical Articles [Chih-Hsiang Leng] Periodical Articles [Chien-Hsiung Pan] Periodical Articles

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