國家衛生研究院 NHRI:Item 3990099045/7100
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    題名: Allergies and risk of head and neck cancer: An original study plus meta-analysis
    作者: Hsiao, JR;Ou, CY;Lo, HI;Huang, CC;Lee, WT;Huang, JS;Chen, KC;Wong, TY;Tsai, ST;Yen, CJ;Wu, YH;Hsueh, WT;Yang, MW;Wu, SY;Chang, JY;Chang, KY;Lin, CL;Wang, FT;Wang, YH;Weng, YL;Yang, HC;Chang, JS
    貢獻者: National Institute of Cancer Research
    摘要: Background: Although the relationship between allergy and cancer has been investigated extensively, the role of allergy in head and neck cancer (HNC) appears less consistent. It is not clear whether allergies can independently influence the risk of HNC in the presence of known strong environmental risk factors, including consumption of alcohol, betel quid, and cigarette. Methods: The current paper reports results from: 1) an original hospital-based case-control study, which included 252 incident cases of HNC and 236 controls frequency-matched to cases on sex and age; and 2) a meta-analysis combining the results of the current case-control study and 13 previously published studies (9 cohort studies with 727,569 subjects and 550 HNC outcomes and 5 case-control studies with 4,017 HNC cases and 10,928 controls). Results: In the original case-control study, we observed a strong inverse association between allergies and HNC [odds ratio = 0.41, 95% confidence interval (CI): 0.27-0.62]. The meta-analysis also indicated a statistically significant inverse association between HNC and allergies [meta-relative risk (RR) = 0.76, 95% CI: 0.63-0.91], particularly strong for allergic rhinitis (meta-RR = 0.55, 95% CI: 0.40-0.76). In addition, the inverse association between allergies and HNC was observed only among men (meta-RR = 0.67, 95% CI: 0.54-0.84) but not among women (meta-RR = 0.98, 95% CI: 0.81-1.18). Conclusions: These findings suggest that immunity plays an influential role in the risk of HNC. Future studies investigating immune biomarkers, including cytokine profiles and genetic polymorphisms, are warranted to further delineate the relationship between allergies and HNC. Understanding the relationship between allergies and HNC may help devise effective strategies to reduce and treat HNC.
    日期: 2013-02-01
    關聯: PLoS ONE. 2013 Feb 1;8(2):Article number e55138.
    Link to: http://dx.doi.org/10.1371/journal.pone.0055138
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000314597900016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84873257418
    顯示於類別:[張俊彥] 期刊論文
    [張光裕] 期刊論文
    [張書銘] 期刊論文

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