國家衛生研究院 NHRI:Item 3990099045/7211
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7211


    Title: Hysterectomy in young women associates with higher risk of stroke: A nationwide cohort study
    Authors: Yeh, JS;Cheng, HM;Hsu, PF;Sung, SH;Liu, WL;Fang, HL;Chuang, SY
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: AbstractBackground and purpose Hysterectomy is a common procedure for treatment of numerous gynecologic diseases. However, reduction of endogenous sex hormone levels has been reported in hysterectomized women, and the association of hysterectomy with the cardiovascular risk remains controversial. We aimed to investigate the influence of hysterectomy on the risk of stroke and coronary heart disease, with adjustment for traditional risk factors. Methods A nationwide population-based study was conducted using the Taiwan National Health Insurance database from 1 million sampling cohort data set. A total of 7605 women who underwent hysterectomy without simultaneous oophorectomy from 1997 to 2009 were identified. The control group consisted of 30,420 women without hysterectomy, selected by matching the age, hypertension, diabetes, dyslipidemia, and the commencement date of follow-up. Results A total of 558 strokes and 599 coronary heart diseases (CHD) developed during a median 7.24 years follow-up. The difference was not significant between women with and without hysterectomy for stroke (2.34 vs. 2.08 per 1000 person-year, p = 0.26) and CHD (2.39 vs. 2.26, p = 0.53). However, of the women who underwent hysterectomy before 45 years, the hazard ratio of hysterectomy was 2.29 (95% CI, 1.52–3.44) for stroke and 1.14 (95% CI, 0.71–1.83) for CHD. Conclusions Categorized by the patients' age at operation, the associations between hysterectomy and the risk of stroke were different. The excess risk of stroke was observed in women who had hysterectomy before 45 years and remained significant even after accounting for baseline cardiovascular risk factors.
    Date: 2013-10
    Relation: International Journal of Cardiology. 2013 Oct;168(3):2616-2621.
    Link to: http://dx.doi.org/10.1016/j.ijcard.2013.03.042
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0167-5273&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000326184400142
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84885618620
    Appears in Collections:[Shao-Yuan Chuang] Periodical Articles

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