國家衛生研究院 NHRI:Item 3990099045/7220
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12189/12972 (94%)
造訪人次 : 954785      線上人數 : 666
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/7220


    題名: An approximate approach to sampling size determination for the equivalence hypothesis
    作者: Hsieh, CY;Liu, JP
    貢獻者: Division of Biostatistics and Bioinformatics
    摘要: The equivalence hypothesis is the correct hypothesis to confirm whether the new test product conforms to the standard reference product. It has many applications to evaluation of generic drug products and other new clinical modalities. The two one-sided tests (TOST) procedure was proposed to test the equivalence hypothesis for two treatments. When the difference in population means between two treatments is not 0, the proportion of the type II error rate allocated to each of the two tails of the central t-distribution cannot be analytically determined. Hence, no close form of the exact sample size for the equivalence hypothesis is available. Currently only approximate formulas are proposed. The resulting sample sizes may provide either insufficient power or unnecessarily excessive power. We suggest an approximate approach with consideration of type II error rates for both one-sided hypotheses to determination of the sample size for the equivalence hypothesis. The results of a numerical study are reported. Remarks on the usage of different methods for the sample size determination for the equivalence hypothesis in practical applications are provided.
    日期: 2013-05
    關聯: Journal of Biopharmaceutical Statistics. 2013 May;23(3):526-538.
    Link to: http://dx.doi.org/10.1080/10543406.2012.755995
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1054-3406&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000317952500003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84877136391
    顯示於類別:[劉仁沛(1998-2002)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SCP84877136391.pdf299KbAdobe PDF680檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋