國家衛生研究院 NHRI:Item 3990099045/7235
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    题名: Statin use and the risk of esophageal cancer: A population-based case-control study
    作者: Chan, TF;Chiu, HF;Wu, CH;Lin, CL;Yang, CY
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Objective: The aim of this study was to investigate whether the use of statins was associated with esophageal cancer risk. Methods: A population-based case-control study was conducted in Taiwan. Cases consisted of all patients who were aged 50 years and older and had a first-time diagnosis of esophageal cancer for the period between 2004 and 2010. The controls were matched to cases by age, sex and index date. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by using multiple logistic regression. Results: A total of 197 esophageal cancer cases and 788 controls were examined. The unadjusted ORs for any statin prescription was 0.86 (95% CI = 0.56-1.34) and the adjusted OR was 0.96 (95% CI = 0.59-1.58). Compared with no use of statins, the adjusted ORs were 0.77 (95% CI = 0.39-1.55) for the group having been prescribed statins with cumulative defined daily dose (DDDs) below 115 and 1.16 (95% CI = 0.63-2.14) for the group with cumulative statin use of 115 DDDs or more. Conclusions: The present data do not provide evidence to support either beneficial or harmful associations between statin use and esophageal cancer risk.
    日期: 2013-05
    關聯: Expert Opinion on Drug Safety. 2013 May;12(3):293-298.
    Link to: http://dx.doi.org/10.1517/14740338.2013.778241
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1474-0338&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000317926600001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84876525094
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