國家衛生研究院 NHRI:Item 3990099045/7238
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7238


    Title: Aryl hydrocarbon receptor controls murine mast cell homeostasis
    Authors: Zhou, Y;Tung, HY;Tsai, YM;Hsu, SC;Chang, HW;Kawasaki, H;Tseng, HC;Plunkett, B;Gao, P;Hung, CH;Vonakis, BM;Huang, SK
    Contributors: Division of Environmental Health and Occupational Medicine
    Abstract: We propose that the aryl hydrocarbon receptor (AhR), a unique chemical sensor, is critical in controlling mast cell differentiation, growth and function in vitro and in vivo. In antigen-stimulated mast cells, exposure to AhR ligands resulted in calcium- and reactive oxygen species (ROS)-dependent increase of reversible oxidation in and reduced activity of SHP-2 phosphatase, leading to enhanced mast cell signaling, degranulation, mediator and cytokine release, as well as the in vivo anaphylactic response. Surprisingly, significant mast cell deficiency was noted in AhR-null mice, due to defective calcium signaling and mitochondrial function, concomitant with reduced expression of c-kit and cytosolic STAT proteins, as well as enhanced intracellular ROS and apoptosis. Consequently, AhR-null mast cells responded poorly to stimulation, demonstrating a critical role of AhR signaling in maintaining mast cell homeostasis.
    Date: 2013-04
    Relation: Blood. 2013 Apr;121(16):3195-3204.
    Link to: http://dx.doi.org/10.1182/blood-2012-08-453597
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-4971&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000321829200022
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84879181079
    Appears in Collections:[Shau-Ku Huang] Periodical Articles

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